2. Signaling Pathways
  3. Immunology/Inflammation
  4. Interleukin Related

Interleukin Related

IL

Interleukin Related

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Interleukins are a group of cytokines (secreted proteins and signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells. Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice.

Interleukin Related Isoform Specific Products:

Interleukin Related Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-163140
    BODIPY-phenyl-amide-alkyne
    BODIPY-phenyl-amide-alkyne (compound 6) is an alkyne-containing OFF-to-ON fluorophore. BODIPY-phenyl-amide-alkyne is a BODIPY derivative that can be conjugated to protein IL-33 Y143azidoPhe via CuAAC reaction.
    BODIPY-phenyl-amide-alkyne
  • HY-P992046
    Anti-IL-18 Antibody
    		Inhibitor
    Anti-IL-18 Antibody is an anti-IL-18 antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-IL-18 Antibody
  • HY-P11122
    MSP-1 P2
    		Activator
    MSP-1 P2 is a synthetic peptide of merozoite surface protein-1 (MSP-1). MSP-1 P2 stimulates umbilical cord blood lymphocytes to produce IFN-γ and IL-13, and this immune response is primarily mediated by CD4+ T cells. MSP-1 P2 can be used as a specific antigen stimulus to detect T cell responses and cytokine levels.
    MSP-1 P2
  • HY-184000
    SIRT5-IN-10
    		Inhibitor
    SIRT5-IN-10 is a competitive SIRT5 inhibitor. SIRT5-IN-10 improves renal function and reduces histopathological damage in septic acute kidney injury (AKI) mice. SIRT5-IN-10 can be used for the research of sepsis-associated AKI.
    SIRT5-IN-10
  • HY-182034
    GAP214
    		Activator
    GAP214 is a monosaccharide lipid A analogue and TLR4/MD-2 complex modulator.GAP214 binds to the TLR4/MD-2 complex via hydrophobic interactions, salt bridges, and hydrogen bonds, induces dimerization of the complex to initiate intracellular signaling cascades.GAP214 functions as an immunostimulant and vaccine adjuvant, enhances antigen-specific IgG antibody production in a mouse model.
    GAP214
  • HY-181509
    TNF-α/IL-1β/IL-6-IN-1
    		Inhibitor
    TNF-α/IL-1β/IL-6-IN-1 is an anti-inflammatory agent. TNF-α/IL-1β/IL-6-IN-1 exerts anti-inflammatory effects by downregulating the expression of pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6, and inhibiting the production of ROS. TNF-α/IL-1β/IL-6-IN-1 upregulates ABCG1 to promote cholesterol efflux. TNF-α/IL-1β/IL-6-IN-1 can be used in the research of inflammatory and lipid metabolic diseases such as atherosclerosis.
    TNF-α/IL-1β/IL-6-IN-1
  • HY-168084
    IL-17-IN-1
    		Inhibitor
    IL-17-IN-1 (26) is an orally active IL-17 inhibitor, with IC50 values of 0.013 μM and 0.004 μM for IL-17A and IL-6 release, respectively. IL-17-IN-1 (26) effectively reduces knee swelling in a rat arthritis model.
    IL-17-IN-1
  • HY-120269
    CAY10512
    		Inhibitor
    CAY10512 is a NF-κB inhibitor. CAY10512 can suppress the upregulation of NF-κB-sensitive proinflammatory miRNAs (miRNA-9, miRNA-125b, miRNA-146a, miRNA-155) in cerebrospinal fluid and extracellular fluid. CAY10512 significantly reduces the release of pro-inflammatory cytokines (such as TNF-α, MCP-1, IL-8, IL-6). CAY10512 can be used for researchs on neuroinflammation, islet transplantation and microRNA regulation.
    CAY10512
  • HY-153952
    Immuno modulator-1
    		Inhibitor
    Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM.
    Immuno modulator-1
  • HY-P991648
    CSL-360
    		Inhibitor
    CSL-360 is a chimeric unconjugated IgG1 monoclonal antibody targeting CD123. CSL-360 efficiently prevents the binding of IL-3 to CD123, abolishing IL-3 induced cell proliferation. CSL-360 can be used for acute myeloid leukemia (AML) research.
    CSL-360
  • HY-W758425
    1-Tetradecanol-d7
    1-Tetradecanol-d7 is the deuterium labeled 1-Tetradecanol (HY-W004294). 1-Tetradecanol is a straight-chain saturated fatty alcohol and antibacterial agent. 1-Tetradecanol can be isolated from Myristica fragrans. 1-Tetradecanol possesses antibacterial and anti-inflammatory (periodontitis) activity.
    1-Tetradecanol-d<sub>7</sub>
  • HY-184201
    Anti-MRSA agent 44
    		Inhibitor
    Anti-MRSA agent 44 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. Anti-MRSA agent 44 exihibits antibiofilm activity against MRSA. Anti-MRSA agent 44 reduces bacterial counts and biofilm burdens, accelerates wound healing, lowers inflammatory cytokine levels in mouse models. Anti-MRSA agent 44 can be used for the research of MRSA skin wound infection and MRSA catheter-associated biofilm infection.
    Anti-MRSA agent 44
  • HY-161821
    Antitumor agent-173
    		Control
    Antitumor agent-173 (Compound 4b) is a prodrug of Cycloicaritin (HY-N1940). Antitumor agent-173 is a substrate for OATP2B1. Antitumor agent-173 selectively inhibits the growth of tumor Antitumor agent-173 significantly increases the oral bioavailability of Cycloicaritin and exerts good antitumor activity and safety.
    Antitumor agent-173
  • HY-183370
    JAK2/STAT3-IN-2
    		Inhibitor
    JAK2/STAT3-IN-2 is an orally active JAK2/STAT3 inhibitor. JAK2/STAT3-IN-2 inhibits the phosphorylation of tyrosine residues in JAK2 and STAT3, blocks downstream signal transduction, disrupts the dimerization and nuclear translocation of STAT3, and suppresses pro-inflammatory transcriptional activity. JAK2/STAT3-IN-2 inhibits the expression of IL-17A and IL-17F, reduces immune cell infiltration, and inhibits the production of NO simultaneously. JAK2/STAT3-IN-2 exerts a protective effect in a mouse model of ulcerative colitis induced by DSS (HY-116282C). JAK2/STAT3-IN-2 can be used for the research of ulcerative colitis.
    JAK2/STAT3-IN-2
  • HY-15499
    K-832
    		Inhibitor
    K-832 is an orally active IL-1β secretion inhibitor. K-832 can be used in the research of rheumatoid arthritis.
    K-832
  • HY-RS06691
    Il15 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Il15 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il15 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Il15 Mouse Pre-designed siRNA Set A
  • HY-120049
    TAK-603
    		Inhibitor
    TAK-603 is a potent and orally active antirheumatic agent. TAK-603 inhibits Thl-type cytokine production. TAK-603 has the potential for the research of adjuvant arthritis.
    TAK-603
  • HY-N12840
    Logmalicid B
    		Inhibitor
    Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research.
    Logmalicid B
  • HY-145087
    NP3-146
    		Inhibitor
    NP3-146 is a NLRP3 inflammasome inhibitor through locking the NACHT domain of NLRP3. NP3-146 shows potent inhibitory activity against IL-1β release with an IC50 value of 0.171 μM in LPS (HY-D1056)/Nigericin (HY-127019)-stimulated BMDM cells. NP3-146 regulates the levels of cleaved Caspase-1 and cleaved IL-1β in cell supernatants. NP3-146 can be used for the research of inflammatory diseases.
    NP3-146
  • HY-W004261R
    Nonadecanoic acid (Standard)
    		Inhibitor
    Nonadecanoic acid (Standard) is the analytical standard of Nonadecanoic acid. This product is intended for research and analytical applications. Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis. Nonadecanoic acid can be isolated from several sources, including fungus, plant, and marine sponge. Nonadecanoic acid exhibits inhibitory effects on fibrinolysis and plasmin activity. Nonadecanoic acid produced from Streptomyces is an anti-tumor agent and inhibits IL-12 production.
    Nonadecanoic acid (Standard)
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Interleukin Related Isoform Comparison

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